Plozasiran (By injection)

Plozasiran

Used to reduce triglycerides (fat in the blood) in patients with familial chylomicronemia syndrome (FCS).

Brand Name(s):

Redemplo

When This Medicine Should Not Be Used:

How to Use This Medicine:

Injectable

• Your doctor will prescribe your exact dose and tell you how often it should be given. This medicine is given as a shot under your skin. It is usually given in your thighs, stomach, or upper arm.
• You may be taught how to give your medicine at home. Make sure you understand all instructions before giving yourself an injection. Do not use more medicine or use it more often than your doctor tells you to.
• You will be shown the body areas where this shot can be given. Use a different body area each time you give yourself a shot. Keep track of where you give each shot to make sure you rotate body areas. Do not inject into skin areas that are bruised, hard, red, tender, or have scars or stretch marks.
• Your doctor will ask you to stay on your low-fat diet while using this medicine.
• Allow 30 minutes for the prefilled syringe to warm up to room temperature. Do not warm using heat sources (including hot water or microwave).
• Check the liquid in the prefilled syringe. It should be clear and colorless to yellow. Do not use it if it is cloudy, discolored, or has particles in it. Do not use the prefilled syringe if it looks damaged, cracked, or broken, if the gray cap is missing or not attached, or if it has been dropped.
• Prefilled syringe:
  • Wash your hands with soap and water before and after using this medicine.
  • Do not remove the gray needle cap until you are ready to inject. Do not pick up or pull the prefilled syringe by the plunger rod or gray needle cap.
  • Hold the prefilled syringe by the syringe barrel, with the needle facing away from you. Pull the gray needle cap straight up. Do not twist or bend the cap. Do not put the needle cap back on.
  • Hold the prefilled syringe in one hand. Gently pinch the skin with your other hand. Insert the needle at a 45 to 90 degree angle. Keep the skin pinched while you are inserting the needle and during injection. Do not put your finger on the plunger head before injecting.
  • Push the plunger head all the way down. Gently lift the syringe up and off the skin until the needle is completely removed. Do not pull the plunger head up. Lift the syringe straight up.
• Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.
• Missed dose: If you miss a dose, inject it as soon as possible. Then, inject the next dose 3 months from the date of your most recent dose to get back on the every-3-month dosing schedule.
• If you store this medicine at home, keep it in the refrigerator. Do not freeze. You may store this medicine at room temperature for up to 30 days. Throw away any unused medicine after 30 days.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

Warnings While Using This Medicine:

• Tell your doctor if you are pregnant or breastfeeding, or if you have liver disease.
• Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
• Keep all medicine out of the reach of children. Never share your medicine with anyone.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

• Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
• Blurred vision, dry mouth, increased thirst, nausea, sweating, trouble breathing

If you notice these less serious side effects, talk with your doctor:

• Headache
• Redness, itching, bump, swelling, or any changes in your skin where the shot was given

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Last Updated: 1/4/2026