Diazoxide choline (By mouth)

Diazoxide Choline (dye-az-OX-ide KOE-leen)

Treats hyperphagia (extreme hunger or urge to eat) in patients with Prader-Willi syndrome.

Brand Name(s):

Vykat XR

When This Medicine Should Not Be Used:

How to Use This Medicine:

Long Acting Tablet

• Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.
• Swallow the extended-release tablet whole. Do not crush, break, or chew it.
• The dose of this medicine is different from diazoxide oral liquid. Do not change between this medicine and other diazoxide products.
• This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.
• Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose. If you miss a dose of 7 days or more, call your doctor or pharmacist for instructions.
• Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep the extended-release tablets in its original container. Do not remove desiccant (drying agent).

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

• Some medicines can affect how diazoxide choline works. Tell your doctor if you are using any of the following:
  • Fluvoxamine, itraconazole, phenytoin, rifampin
  • Blood thinner (including warfarin)
  • Diuretic (water pill), especially a thiazide
  • Growth hormone
  • Medicine to lower blood sugar
  • Steroid medicine

Warnings While Using This Medicine:

• Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, heart disease, dehydration, diabetes, low blood sugar, any type of illness, or a history of fluid retention (edema). Tell your doctor if you drink alcohol or plan to have surgery.
• This medicine may cause the following problems:
  • High blood sugar
  • Fluid overload (too much fluid in the body)
• Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
• Keep all medicine out of the reach of children. Never share your medicine with anyone.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

• Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
• Blistering, peeling, red skin rash
• Blurred vision, dry mouth, increased hunger, sweating, trouble breathing, weight loss
• Fever, chills, cough, runny or stuffy nose, sore throat, body aches
• Nausea, vomiting, stomach pain
• Rapid weight gain, swelling in your hands, ankles, or feet
• Unusual bleeding, bruising, or weakness

If you notice these less serious side effects, talk with your doctor:

• Increased hair growth on forehead, back, arms, and legs
• Joint pain

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Last Updated: 5/4/2025