Suzetrigine (By mouth)

Suzetrigine (soo-ZE-tri-jeen)

Treats moderate to severe short-term pain.

Brand Name(s):

Journavx

When This Medicine Should Not Be Used:

How to Use This Medicine:

Tablet

• Your doctor will tell you how much medicine to use. Do not use more than directed.
• Swallow the tablet whole. Do not chew or crush it.
• Take the first dose at least 1 hour before or 2 hours after food. You may drink clear liquids (including water, apple juice, vegetable broth, tea, or black coffee). For the second dose, you may take it with or without food.
• This medicine is not for long-term use.
• Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.
• Missed dose:
  • If you miss a dose and you do not have liver disease: Take the missed dose as soon as possible then go back to your regular dosing schedule. If you miss 2 or more doses, take 2 tablets and go back to your regular schedule.
  • If you miss a dose and you have liver disease: Take the missed dose as soon as possible. If you took the missed dose and your next dose is within 6 hours, skip the next dose and go back to your regular dosing schedule.
• Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

• Do not use this medicine together with itraconazole.
• Some medicines can affect how suzetrigine works. Tell your doctor if you are using efavirenz, fluconazole, midazolam, or rifampin.
• Do not eat grapefruit or drink grapefruit juice while you are using this medicine.

Warnings While Using This Medicine:

• Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease or liver disease.
• If you are using this medicine together with birth control pills (including progestins other than levonorgestrel and norethindrone), use two forms of effective birth control, including condom, ethinyl estradiol, or diaphragm during treatment and for 28 days after the last dose.
• Using this medicine may temporarily reduce the chance of getting pregnant. If you are using any type of birth control, you should continue using it during treatment with this medicine. Talk with your doctor if you have concerns about this.
• Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
• Keep all medicine out of the reach of children. Never share your medicine with anyone.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

• Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
• Fast, slow, or uneven heartbeat
• Lightheadedness or fainting
• Unusual bruising

If you notice these less serious side effects, talk with your doctor:

• Itching skin
• Muscle spasm

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Last Updated: 5/4/2025