Drug Notes - Pentostatin (By injection)

Pentostatin (By injection)

There may be other brand names for this medicine.

This medicine is not right for everyone. You should not receive it if you had an allergic reaction to pentostatin or if you are pregnant.

Your doctor will prescribe your dose and schedule. This medicine is given through an IV placed in a vein. This medicine must be given slowly, so the IV will have to stay in place for at least 20 to 30 minutes.
A nurse or other health provider will give you this medicine.

Do not use fludarabine while you are using this medicine.
Some medicines can affect how pentostatin works. Tell your doctor if you are using allopurinol, carmustine, cyclophosphamide, etoposide, or vidarabine.

This medicine may cause birth defects if either partner is using it during conception or pregnancy. Tell your doctor right away if you or your partner becomes pregnant. If you are female and able to get pregnant, your doctor may do tests to make sure you are not pregnant before receiving this medicine. Use an effective form of birth control while you are receiving this medicine and for 6 months after the last dose. Males who are receiving this medicine, with female partners who can become pregnant, must use an effective birth control during treatment and for 3 months after the last dose of this medicine.
Do not breastfeed during treatment and for 1 week after the last dose.
Tell your doctor if you have kidney disease, liver disease, lung disease, low blood pressure, or any type of infection.
This medicine may cause the following problems:
- Lung or breathing problems, including pulmonary edema
- Hypotension (low blood pressure)
This medicine may make you bleed, bruise, or get infections more easily. Take precautions to prevent illness and injury. Wash your hands often.
Medicines used to treat cancer are very strong and can have many side effects. Before receiving this medicine, make sure you understand all the risks and benefits. It is important for you to work closely with your doctor during your treatment.
Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
Blue lips and fingernails, chest pain
Confusion, extreme tiredness, or drowsiness
Dark urine or pale stools, loss of appetite, nausea, vomiting, stomach pain, yellow skin or eyes
Decrease in how much or how often you urinate
Fever, chills, cough, runny or stuffy nose, sore throat, body aches
Lightheadedness or fainting
Rapid weight gain, swelling in your hands, ankles, or feet
Unusual bleeding, bruising, or weakness

Last Updated: 1/4/2026